Quantification of the temporal change of diffusion patterns following mild traumatic brain injury Authors

Despite the emerging applications of diffusion tensor imaging (DTI) [1,4], there is a lack of longitudinal investigation on the evolution of diffusion based patterns in mild traumatic brain injury (mTBI), which may help to predict the recovery and assist in studying the long term impact caused by mTBI. Although the newly developed DTI techniques, such as voxel-wise analysis, region of interest (ROI) based analysis and tractography [3], have demonstrated their capability to detect mTBI related regions, they are not effective solutions for quantification of the temporal changes of mTBI. Furthermore, these methods rely on statistical analysis based on reasonably large data samples, which may not be suitable for case studies, such as tracking recovery of function in an individual.